My publications


Summary: 45 original research articles, 4 reviews, 1 book chapter and 5 patents.


See my ORCID record or my Researcher ID account (H-index=18).


Year Manuscript IF*
2002 Larsen, M.*, Jensen, K. B.*, Pedersen, J. S., Christensen, P. A., Alvarez-Vallina, L., Goletz, S., Clark, B. F. and Kristensen, P., Functional improvement of antibody fragments using a novel phage coat protein III fusion system. Biochem Biophys Res Commun 2002. 298: 566-573.(link)

* Authors contributed equally

  Larsen, M., Goletz, S., Jensen, K. B., Christensen, P. A. and Kristensen, P., Aktive Fusionsproteine und Verfahren zu ihrer Herstellung, Patent, Germany. WO2004018685. 2002. NA
2004 Ravn, P., Danielczyk, A., Jensen, K. B., Kristensen, P., Christensen, P. A., Larsen, M., Karsten, U. and Goletz, S., Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen-Friedenreich antigen. J Mol Biol 2004. 343: 985-996.(link) 4.3
2006 Cuesta, A. M., Suarez, E., Larsen, M., Jensen, K. B., Sanz, L., Compte, M., Kristensen, P. and Alvarez-Vallina, L., Enhancement of DNA vaccine potency through linkage of antigen to filamentous bacteriophage coat protein III domain I. Immunology 2006. 117: 502-506.(link) 3.8
  Sauce, D., Larsen, M., Curnow, S. J., Leese, A. M., Moss, P. A., Hislop, A. D., Salmon, M. and Rickinson, A. B., EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15. Blood 2006. 108: 11-18.(link)
  Schilling, R., Heil, A., Langner, K., Pohlmeyer, K., Larsen, M., Baumeister, H., Goletz, S. and Behnke, B., A multivalent HIV-vaccine: development of a plasmid DNA for the expression of HIV envelope glycoproteins with hypervariable V3-loop domains. Vaccine 2006. 24: 4648-4650.(link) 3.6
  Taylor, G. S., Long, H. M., Haigh, T. A., Larsen, M., Brooks, J. and Rickinson, A. B., A role for intercellular antigen transfer in the recognition of EBV-transformed B cell lines by EBV nuclear antigen-specific CD4+ T cells. J Immunol 2006. 177: 3746-3756.(link) 4.9
2007 Sauce, D., Almeida, J. R., Larsen, M., Haro, L., Autran, B., Freeman, G. J. and Appay, V., PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS 2007. 21: 2005-2013.(link) 5.6
  Sauce, D., Larsen, M., Leese, A. M., Millar, D., Khan, N., Hislop, A. D. and Rickinson, A. B., IL-7R alpha versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue. J Infect Dis 2007. 195: 268-278.(link) 6.0
2008 Appay, V. and Larsen, M., Samples isolated by Fluorescent Activated Cell Sorting (FACS) Progress in Inflammation Research - Microarrays in Inflammation 2008, pp 59-70. NA
  Larsen, M., Jensen, K. B., Christensen, P. A., Suarez, E., Paris, D., Sanz, L., Ravn, P., Sauce, D., Saas, P., Goletz, S., Alvarez-Vallina, L. and Kristensen, P., Functionally fused antibodies--a novel adjuvant fusion system. J Immunol Methods 2008. 339: 220-227. (link) 1.8
2009 Almeida, J. R., Sauce, D., Price, D. A., Papagno, L., Shin, S. Y., Moris, A., Larsen, M., Pancino, G., Douek, D. C., Autran, B., Saez-Cirion, A. and Appay, V., Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 2009. 113: 6351-6360.(link) 10.5 
  Christensen, P. A., Danielczyk, A., Ravn, P., Larsen, M., Stahn, R., Karsten, U. and Goletz, S., Modifying antibody specificity by chain shuffling of V / V between antibodies with related specificities. Scand J Immunol 2009. 69: 1-10.(link) 1.7
   Sauce, D., Larsen, M., Abbott, R. J., Hislop, A. D., Leese, A. M., Khan, N., Papagno, L., Freeman, G. J. and Rickinson, A. B., Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection. J Virol 2009. 83: 9068-9078.(link) 4.4
  Sauce, D., Larsen, M., Fastenackels, S., Duperrier, A., Keller, M., Grubeck-Loebenstein, B., Ferrand, C., Debre, P., Sidi, D. and Appay, V., Evidence of premature immune aging in patients thymectomized during early childhood. J Clin Invest 2009. 119: 3070-3078.(link) 13.3
2010 Xie, J., Lu, W., Samri, A., Costagliola, D., Schnuriger, A., da Silva, B. C., Blanc, C., Larsen, M., Theodorou, I., Rouzioux, C. and Autran, B., Distinct differentiation profiles of HIV-Gag and Nef-specific central memory CD8+ T cells associated with HLA-B57/5801 and virus control. AIDS 2010. 24: 2323-2329.(link) 5.6
2011 Arnaud, L., Gorochov, G., Charlotte, F., Lvovschi, V., Parizot, C., Larsen, M., Ghillani-Dalbin, P., Hervier, B., Kahn, J. E., Deback, C., Musset, L., Amoura, Z. and Haroche, J., Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients. Blood 2011. 117: 2783-2790.(link) 10.5
  Arnaud, L., Larsen, M. and Gorochov, G., Antagonistic T-cell subsets in skin diseases. N Engl J Med 2011. 365: 1450-1452.(link) 55.9
  Larsen, M., Arnaud, L., Hie, M., Parizot, C., Dorgham, K., Shoukry, M., Kemula, M., Barete, S., Derai, D., Sauce, D., Amoura, Z., Pene, J., Yssel, H. and Gorochov, G., Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets. Eur J Immunol 2011. 41: 2596-2605. (link) 4.2
  Larsen, M., Sauce, D., Deback, C., Arnaud, L., Mathian, A., Miyara, M., Boutolleau, D., Parizot, C., Dorgham, K., Papagno, L., Appay, V., Amoura, Z. and Gorochov, G., Exhausted cytotoxic control of Epstein-Barr virus in human lupus. PLoS Pathog 2011. 7: e1002328. (link)
  Papagno, L., Alter, G., Assoumou, L., Murphy, R. L., Garcia, F., Clotet, B., Larsen, M., Braibant, M., Marcelin, A. G., Costagliola, D., Altfeld, M., Katlama, C. and Autran, B., Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine. AIDS 2011. 25: 27-36.(link) 5.6
  Sauce, D., Larsen, M., Fastenackels, S., Pauchard, M., Ait-Mohand, H., Schneider, L., Guihot, A., Boufassa, F., Zaunders, J., Iguertsira, M., Bailey, M., Gorochov, G., Duvivier, C., Carcelain, G., Kelleher, A. D., Simon, A., Meyer, L., Costagliola, D., Deeks, S. G., Lambotte, O., Autran, B., Hunt, P. W., Katlama, C. and Appay, V., HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis. Blood 2011. 117: 5142-5151.(link) 10.5
2012 Larsen, M., Gorochov, G., Sauce, D. and Arnaud, L., Method for determining the polyfunctionality of cells and its applications. Patent WO2013127904. 2012.
  Larsen, M., Sauce, D., Arnaud, L., Fastenackels, S., Appay, V. and Gorochov, G., Evaluating cellular polyfunctionality with a novel polyfunctionality index. PLoS One 2012. 7: e42403. (link)
  Lvovschi, V., Arnaud, L., Parizot, C., Freund, Y., Juillien, G., Ghillani-Dalbin, P., Bouberima, M., Larsen, M., Riou, B., Gorochov, G. and Hausfater, P., Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: a prospective observational study. PLoS One 2012. 6: e28870. (link)
  Mathian, A., Parizot, C., Dorgham, K., Trad, S., Arnaud, L., Larsen, M., Miyara, M., Hie, M., Piette, J. C., Frances, C., Yssel, H., Amoura, Z. and Gorochov, G., Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann Rheum Dis 2012. 71: 1227-1234.(link) 10.4
  Sauce, D., Larsen, M., Fastenackels, S., Roux, A., Gorochov, G., Katlama, C., Sidi, D., Sibony-Prat, J. and Appay, V., Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults. J Immunol 2012.(link) 4.9
2013 Larsen, M., Appay, V. and Sauce, D., [Influence of PD-1 on the immunological synapse: a facet of immune regulation ?]. Med Sci (Paris) 2013. 29: 1080-1082. (link)
  Roux, A., Mourin, G., Fastenackels, S., Almeida, J. R., Iglesias, M. C., Boyd, A., Gostick, E., Larsen, M., Price, D. A., Sacre, K., Douek, D. C., Autran, B., Picard, C., Miranda, S., Sauce, D., Stern, M. and Appay, V., CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation. Clin Immunol 2013. 148: 16-26.(link) 3.7
  Roux, A., Mourin, G., Larsen, M., Fastenackels, S., Urrutia, A., Gorochov, G., Autran, B., Donner, C., Sidi, D., Sibony-Prat, J., Marchant, A., Stern, M., Sauce, D. and Appay, V., Differential Impact of Age and Cytomegalovirus Infection on the gammadelta T Cell Compartment. J Immunol 2013; 191:1300-6.(link) 4.9
2014 Hill, B. J., Darrah, P. A., Ende, Z., Ambrozak, D. R., Quinn, K. M., Darko, S., Gostick, E., Wooldridge, L., van den Berg, H. A., Venturi, V., Larsen, M., Davenport, M. P., Seder, R. A., Price, D. A. and Douek, D. C., Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations. J Immunol 2014; 193: 5626-5636.(link) 4.9
  Smolen, K. K., Cai, B., Gelinas, L., Fortuno, E. S., 3rd, Larsen, M., Speert, D. P., Chamekh, M., Cooper, P. J., Esser, M., Marchant, A. and Kollmann, T. R., Single-Cell Analysis of Innate Cytokine Responses to Pattern Recognition Receptor Stimulation in Children across Four Continents. J Immunol 2014 Sep 15;193(6):3003-12.(link) 4.9
2015 Goulenok, T., Boyd, A., Larsen, M., Fastenackels, S., Boccara, F., Meynard, J. L., Hadour, N., Samri, A., Desvarieux, M., Autran, B., Appay, V., Girard, P. M. and Sauce, D., Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients. AIDS 2015. 29: 287-293. (link)
  Huygens, A., Lecomte, S., Tackoen, M., Olislagers, V., Demarcelle, Y., Burny, W., Van Rysselberge, M., Liesnard, C., Larsen, M., Appay, V., Donner, C. and Marchant, A., Functional exhaustion limits CD4+ and CD8+ T cell responses to congenital cytomegalovirus infection. J Infect Dis 2015; 212(3):484-94. (link)
  Plaza Onate, F., Batto, J., Juste, C., Fadlallah, J., Fougeroux, C., Gouas, D., Pons, N., Kennedy, S., Levenez, F., Dore, J., Ehrlich, S., Gorochov, G. and Larsen, M., Quality control of microbiota metagenomics by k-mer analysis. BMC Genomics 2015. 16: 183. (link)
  Boyd, A., Almeida, J., Darrah, P., Sauce, D., Seder, R., Appay, V., Gorochov, G. and Larsen, M., Pathogen-specific T cell polyfunctionality is a correlate of T cell efficacy and immune protection. PLoS One 10(6), e0128714 (link)
  Gorochov, G., Larsen, M., Parizot, C., Brisson, H., Nienen, M., Kuchenbecker, L., Babel, N., and Neumann, A. U., On the difficulty of defining donor-reactive T cell repertoire signatures in transplant recipients. Science Translational Medicine2015 Jul 22;7(297):297le1 (link)
  Dorgham, K., Amoura, Z., Parizot, C., Arnaud, L., Frances, C., Pionneau, C., Devilliers, H., Pinto, S., Zoorob, R., Miyara, M., Larsen, M., Yssel, H., Gorochov, G. and Mathian, A.., Ultraviolet light converts propranolol, a nonselective β-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand. Eur J Immunol. 2015; Sep 10; 45(11):3174-87. (link)
2016 Lissina, A., Afonso, G., Larsen, M., Gostick, E., Price, D. A., Mallone, R. and Appay, V., Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand.  J Immunol. 2016;  Jan 1;196(1):256-63. (link)
  Bayard, C., Lepetitcorps, H., Roux, A.,  Larsen, M., Fastenackels, S., Salle, V., Vieillard, V., Marchant, A., Stern, M., Boddaert, J., Bajolle, F., Appay, V. and Sauce, D., Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans. Eur J Immunol 2016;  May; 46(5):1168-79 (link)
  Sauce, D., Gorochov, G. and Larsen, M., HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy.  Scientific Reports 2016; June; 6:28129 (link) 5.6
  Samri, A., Bacchus-Souffan, C., Hocqueloux, L., Avettand-Fenoel, V., Descours, B., Theodorou, I., Larsen, M., Saez-Cirion, A., Rouzioux, C., Autran, B.; ANRS VISCONTI study group, Polyfunctional HIV-specific T-cells in post-treatment controllers. AIDS 2016; Sep 24; 24;30(15):2299-302 (link) 5.6
  Moor, K., Fadlallah, J., Toska, A., Sterlin, D., Balmer, M. L., Macpherson, A. J., Gorochov, G., Slack, E.* and Larsen, M.*, Analysis of bacterial surface-specific antibodies in body fluids using bacterial flow cytometry. Nature Protocols 2016; Aug; 11(8):1531-1553 (*Jointly directed the work).(link) 9.7
  El Kafsi, H., Gorochov, G. and Larsen, M., Host genetics affect microbial ecosystems via host immunity. Current Opinion in Allergy and Clinical Immunology 2016; Oct; 16(5):413-20 (link)
  Bajwa, M., Vita, S., Vescovini, S., Larsen, M., Sansoni, P., Terrazzini, N., Caserta, S., Thomas, D., Davies, K., Smith, H. and Kern, F., Functional diversity of CMV-­specific T cells is maintained in older people and significantly associated with protein specificity and response size. The Journal of Infectious Diseases 2016; Nov 1;214(9):1430-1437.(link) 6,3
  Larsen, M., Sauce, D., Appay, V. and Boddeart, J., Methods for predicting the survival time of a subject. Patent EP16306120. 2016
2017 Fadlallah, J., El Kafsi, H. and Larsen, M., Retour à l'équilibre - Le microbiote impliqué. Science & Sante 2017 34:30-32 (link) NA
  Bajwa, M., Vita, S., Vescovini, S., Larsen, M., Sansoni, P., Terrazzini, N., Caserta, S., Thomas, D., Davies, K., Smith, H. and Kern, F., CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival. The Journal of Infectious Diseases 2017 Apr 15; 215(8):1212-1220. 6.3
  Cardinaud, S., Urrutia, A., Rouers, A., Coulon, P.G., Kervevan, J., Richetta, C., Bet, A., Maze, E.A., Larsen, M., Iglesias, M.C., Appay, V., Graff-Dubois, S. and Moris, A., Triggering of TLR-3, -4, NOD2, and DC-SIGN reduces viral replication 1 and increases 2 T-cell activation capacity of HIV-infected human dendritic cells. Eur J Immunol. 2017 Mar; 47(5):818-829 (link) 4.2
  El Kafsi, H., Gorochov, G. and Larsen, M., La génétique de l’hôte influe sur les écosystèmes microbiens par l’intermédiaire du système immunitaire de l’hôte. Biol Aujourdhui 2017; 211(1):39-49 (link)
  Larsen, M., Bayard, C., Lepetitcorps, H., Cohen-Bittan, J., Appay, V., Boddaert, J. and Sauce, D. Elevated Neopterin levels predict early death in older hip-fracture patients. EBioMedicine 2017 Dec; 26:157-164 (link)
  2018 Lahmar, O., Salhi, M., Kaabachi, W., Berraies, A., Ammar, J., Hussain Soomro, M., Larsen, M., Annesi‑Maesano, I., Hamzaoui, K., Hamzaoui, A. Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Tunisian Adults’ Asthma. Lung 2018; (link) 1.9
  Fadlallah, J., El Kafsi, H., Sterlin, D., Juste, C., Parizot, C., Dorgham, K., Autaa, G., Gouas, D., Almeida, M., Lepage, P., Pons, N., Le Chatelier, E., Levenez, F., Kennedy, S., Galleron, N., Pais de Barros, J-P., Malphettes, M., Galicier, L., Boutboul, D., Mathian, A., Miyara, M., Oksenhendler, E., Amoura, Z., Doré, J., Fieschi, C., Ehrlich, S.D., Gorochov, G.* and Larsen, M.Microbial ecology perturbation in human IgA deficiency. Science Translational Medicine 2018 May; 10(439):eaan1217; DOI:10.1126/scitranslmed.aan1217(*Jointly directed the work) (link)  16.8
  Larsen, M., Fadlallah, J., Sterlin, D. and Gorochov, G. IVIG composition and method of treatment of antibody deficient patients. Patent EP18306409. 2018 NA
  Larsen, M., Fadlallah, J., Sterlin, D. and Gorochov, G. Composition for the treatment of antibody deficiencies. Patent EP18306410. 2018 NA
  Sterlin, D., Fieschi, C., Malphettes, M., Larsen, M., Gorochov, G. and Fadlallah, J. Immune/microbial interface perturbation in human IgA deficiency. Gut Microbes 2018 Nov; DOI:10.1080/19490976.2018.1546520 (link) NA
  Fadlallah, J., Sterlin, D., Fieschi, C., Parizot, C., Dorgham, K., El Kafsi, H., Autaa, G., Ghillani-Dalbin, P., Juste, C., Lepage, P., Malphettes, M., Galicier, L., Boutboul, D., Clément, K., André, S., Marquet, F., Tresallet, C., Mathian, A., Miyara, M., Oksenhendler, E., Amoura, Z., Yssel, H., Gorochov, G.* and Larsen, M.* Synergistic convergence of microbiota-specific systemic IgG and secretory IgA. JACI, Dec; 6749(18)31570-7. (*Jointly directed the work) (link)  12.5

*IF = Impact Factor

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